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Alex and Charlie are caught in the middle of a shooting on their way to their first shift back at Hope Zion. In the midst of the commotion, Alex treats a bullied teenager and deals with her own emotions about everything that’s happened in the past year. Meanwhile, Charlie is caught off guard when he realizes that he’s still able to see the spirits of deceased patients. As well, new Chief of Surgery Joel works alongside Charlie’s ex-wife Dawn to perform an intense surgery.
Alex must learn to stick up for herself and not be intimidated by Dawn (Charlie’s ex-wife) in order to work alongside her and perform a minimally invasive heart procedure to save a patient’s life. Meanwhile, Joel unlocks a mystery to a young girl’s disease, while getting some advice from Charlie, who is trying to figure out how to help his comatose patient come back from being a spirit. It’s a week of defying the odds at Hope Zion Hospital.
Alex is trying to get her life back to normal with Charlie and at Hope Zion Hosital – but with Charlie’s head in the clouds and the pressure to find her medical niche – she’s struggling. Inspiration comes in the form of an immigrant doctor who needs Alex to save his wife’s life, and in return, helps her find her calling.
The doctors at Hope Zion Hospital are forced to deal with people from their past as Alex, Charlie and Joel take on the daunting task of operating on a malpractice lawyer known for suing every doctor in his path. Meanwhile, Zach is tested when the last person he wants to treat comes into his E.R. and a Season 1 patient returns with some difficult insight for Charlie and Alex.
Alex must become the unlikely advocate for a violent young prisoner brought in to Hope Zion Hospital, while Joel connects with a disfigured refugee and tries to convince Dr. Dana Kinney to come back to operate on him. Meanwhile, a spirit who is familiar to many Hope Zion doctors shows up in the morgue when Charlie is about to do routine procedure.
After a young, healthy and hunky fireman dies suddenly at Hope Zion Hospital, Alex must take the stand at Hope Zion’s Morbidity and Mortality (M&M) Rounds to find out what went wrong and who is to blame. Meanwhile, Charlie deals with a nervous aspiring Nun, and Joel has to decide if he can be the man that comes through for Sonja.
When a heat wave hits the city, Alex is appointed Trauma Team Leader as the hospital is faced with an influx of patients during a blackout. With no back-up power available, Dawn and Charlie must figure out a way to continue their surgery as Joel and Maggie attempt to keep a patient alive while stuck in an elevator.
When Alex and Joel end up stranded in the middle of nowhere with a severely injured couple, they’re forced to use only what’s around them to stabilize the pair until paramedics arrive. Meanwhile, back at Hope Zion Hospital, Charlie must try to save the wounded leg of his former college roommate as Gavin attempts to help Shahir improve his bedside manner.
When Alex is forced to put a patient’s gender reassignment surgery on hold, she discovers a secret in his medical history that could save his surgery, but tear his life apart. Charlie deals with a patient who is healthy, sane – and convinced she is going to die at midnight. Meanwhile, Joel secretly helps Sonja deal with a patient of hers who’s been admitted to Hope Zion Hospital.
When Alex’s brother Luke is admitted to Hope Zion Hospital in critical condition, Joel and Charlie must work together to keep him alive while keeping his admittance a secret from Alex. Meanwhile, Alex figures out a way to remove a tumour from a patient pregnant with twins, while Maggie is thrown off her game by the patient’s gorgeous OB/GYN.
Alex risks a dangerous surgery on a seemingly inoperable tumor to save a young boy’s life. Meanwhile, Joel struggles with the challenges of being Chief of Surgery as Charlie struggles with the spirit of Alex’s dead brother Luke.
With one of the Hope Zion doctors’ life at risk, Alex must put her personal and professional reservations aside in order to perform a surgery that could save their life. Meanwhile, a patient's routine check-up proves deadly, and Joel is left to uncover a medical conspiracy that extends far beyond Hope Zion Hospital. Charlie attempts to help Joel unravel the mystery, but ends up preoccupied with helping his patient's spirit.
Alex is surprised twice in one night – first when she realizes she's been tricked into a blind double date, and again when she has to rush her mystery man to the ER. Meanwhile, Charlie works to help a soldier move past a traumatic experience, and Maggie discovers a patient has a contagious illness that could put her pregnancy at risk.
Alex is on her way home to unwind after a long day at work – but all that changes when she witnesses a traumatic accident and is forced to return to work, where the Hope Zion Hospital doctors must work tirelessly against the clock to save a problematic John Doe. Meanwhile, Charlie and Gavin explore Charlie's relationship to the Spirit World in a therapy session.
Alex and Charlie work on a couple who have been mauled by a bear, but as they delve further into the case, begin to suspect that everything is not as it seems. Meanwhile, a Buddhist with a spinal problem tries to teach Joel a lesson.
When a traffic jam gets in the way of an organ delivery for a delicate patient, Alex races against the clock to find a replacement. Meanwhile, Joel helps a bickering, injured couple, and a Spirit pushes Charlie to his breaking point.
Buried secrets come to light as Alex treats an elderly patient whose unusual symptoms have her convinced she’s living in a different era. Charlie and Joel get competitive as their patients pit their surgeons against each other. And Maggie agrees to shadow Dr. Kalfas for a surgery, but has to take the reins when complications arise.
After Dawn diagnoses her with an irregular heartbeat, Alex is supposed to be resting up – but before she gets the chance, The Great Randall returns to Hope Zion Hospital after an experimental cancer treatment gone wrong. Meanwhile, Charlie struggles with the implications of his fight with Joel, who is trying to treat a troubled mathematician.
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